Once it is in your system, you are not going to get it out. Ok, maybe today. But as the fight goes on, they will win if they get the first attack.
For example, I see them create a dummy key in the registry under run. It watches for it to be removed and reboots the system.
The are already watching that key. Try deleting it and press F5. It comes back. I have seen it many times. It doesn't take much more work to reboot the computer. Crappy spyware already crash the system.
At that point...